Substitution of vaccinia virus Elstree by modified vaccinia virus Ankara to test the virucidal efficacy of chemical disinfectants.
Identifieur interne : 003795 ( Main/Exploration ); précédent : 003794; suivant : 003796Substitution of vaccinia virus Elstree by modified vaccinia virus Ankara to test the virucidal efficacy of chemical disinfectants.
Auteurs : S. Hartnack [Allemagne] ; S. Essbauer ; U. TruyenSource :
- Zoonoses and public health [ 1863-1959 ] ; 2008.
Descripteurs français
- KwdFr :
- Allemagne (MeSH), Cellules cultivées (MeSH), Désinfectants (pharmacologie), Désinfection (méthodes), Humains (MeSH), Relation dose-effet des médicaments (MeSH), Vaccin antivariolique (effets indésirables), Vaccin antivariolique (immunologie), Vaccine (prévention et contrôle), Variole (prévention et contrôle), Virus de la vaccine (classification), Virus de la vaccine (effets des médicaments et des substances chimiques), Virus de la vaccine (immunologie), Virus de la variole (effets des médicaments et des substances chimiques).
- MESH :
- effets des médicaments et des substances chimiques : Virus de la vaccine, Virus de la variole.
- effets indésirables : Vaccin antivariolique, Virus de la vaccine.
- immunologie : Vaccin antivariolique, Virus de la vaccine.
- méthodes : Désinfection.
- pharmacologie : Désinfectants.
- prévention et contrôle : Vaccine, Variole.
- Allemagne, Cellules cultivées, Humains, Relation dose-effet des médicaments.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Cells, Cultured (MeSH), Disinfectants (pharmacology), Disinfection (methods), Dose-Response Relationship, Drug (MeSH), Germany (MeSH), Humans (MeSH), Smallpox (prevention & control), Smallpox Vaccine (adverse effects), Smallpox Vaccine (immunology), Vaccinia (prevention & control), Vaccinia virus (classification), Vaccinia virus (drug effects), Vaccinia virus (immunology), Variola virus (drug effects).
- MESH :
- chemical , adverse effects : Smallpox Vaccine.
- chemical , immunology : Smallpox Vaccine.
- chemical , pharmacology : Disinfectants.
- geographic : Germany.
- classification : Vaccinia virus.
- drug effects : Vaccinia virus, Variola virus.
- immunology : Vaccinia virus.
- methods : Disinfection.
- prevention & control : Smallpox, Vaccinia.
- Cells, Cultured, Dose-Response Relationship, Drug, Humans.
Abstract
After the eradication of variola in 1980, the smallpox vaccination was considered to be no longer required and was subsequently abandoned mainly because of possible adverse effects of vaccinia virus especially in first-time vaccinees. Despite a growing number of humans without immunity against vaccinia virus, vaccinia virus Lister Elstree (VACV) is still prescribed for testing virucidal efficacy of chemical disinfectants in the guidelines of the German Veterinary Medical Society [Deutsche Veterinärmedizinische Gesellschaft (DVG)], the German Association for the Control of Virus Diseases [Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten (DVV)] and the Robert Koch Institute (RKI). To evaluate a possible substitution of VACV, with the attenuated modified vaccinia virus Ankara (MVA) the virucidal efficacy of four different DVG-listed commercially available chemical disinfectants representing different groups of chemicals was tested against these two viruses. Quantitative suspension tests and qualitative carrier tests with poplar wood and gauze were performed. Distinction of VACV and MVA was confirmed by cytopathogenic effects, such as differences in plaque morphology. No significant difference in disinfection efficacy between VACV and MVA was observed for any of the disinfectants tested. Implying that vaccinia virus poses a risk after inadvertent inoculation, our results show that MVA, which does not replicate in humans, should replace VACV in the chemical disinfectant testing guidelines.
DOI: 10.1111/j.1863-2378.2007.01094.x
PubMed: 18234028
Affiliations:
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Despite a growing number of humans without immunity against vaccinia virus, vaccinia virus Lister Elstree (VACV) is still prescribed for testing virucidal efficacy of chemical disinfectants in the guidelines of the German Veterinary Medical Society [Deutsche Veterinärmedizinische Gesellschaft (DVG)], the German Association for the Control of Virus Diseases [Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten (DVV)] and the Robert Koch Institute (RKI). To evaluate a possible substitution of VACV, with the attenuated modified vaccinia virus Ankara (MVA) the virucidal efficacy of four different DVG-listed commercially available chemical disinfectants representing different groups of chemicals was tested against these two viruses. Quantitative suspension tests and qualitative carrier tests with poplar wood and gauze were performed. Distinction of VACV and MVA was confirmed by cytopathogenic effects, such as differences in plaque morphology. No significant difference in disinfection efficacy between VACV and MVA was observed for any of the disinfectants tested. Implying that vaccinia virus poses a risk after inadvertent inoculation, our results show that MVA, which does not replicate in humans, should replace VACV in the chemical disinfectant testing guidelines.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18234028</PMID><DateCompleted><Year>2008</Year><Month>05</Month><Day>19</Day></DateCompleted><DateRevised><Year>2008</Year><Month>01</Month><Day>31</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1863-1959</ISSN><JournalIssue CitedMedium="Print"><Volume>55</Volume><Issue>2</Issue><PubDate><Year>2008</Year></PubDate></JournalIssue><Title>Zoonoses and public health</Title><ISOAbbreviation>Zoonoses Public Health</ISOAbbreviation></Journal><ArticleTitle>Substitution of vaccinia virus Elstree by modified vaccinia virus Ankara to test the virucidal efficacy of chemical disinfectants.</ArticleTitle><Pagination><MedlinePgn>99-105</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1863-2378.2007.01094.x</ELocationID><Abstract><AbstractText>After the eradication of variola in 1980, the smallpox vaccination was considered to be no longer required and was subsequently abandoned mainly because of possible adverse effects of vaccinia virus especially in first-time vaccinees. Despite a growing number of humans without immunity against vaccinia virus, vaccinia virus Lister Elstree (VACV) is still prescribed for testing virucidal efficacy of chemical disinfectants in the guidelines of the German Veterinary Medical Society [Deutsche Veterinärmedizinische Gesellschaft (DVG)], the German Association for the Control of Virus Diseases [Deutsche Vereinigung zur Bekämpfung der Viruskrankheiten (DVV)] and the Robert Koch Institute (RKI). To evaluate a possible substitution of VACV, with the attenuated modified vaccinia virus Ankara (MVA) the virucidal efficacy of four different DVG-listed commercially available chemical disinfectants representing different groups of chemicals was tested against these two viruses. Quantitative suspension tests and qualitative carrier tests with poplar wood and gauze were performed. Distinction of VACV and MVA was confirmed by cytopathogenic effects, such as differences in plaque morphology. No significant difference in disinfection efficacy between VACV and MVA was observed for any of the disinfectants tested. Implying that vaccinia virus poses a risk after inadvertent inoculation, our results show that MVA, which does not replicate in humans, should replace VACV in the chemical disinfectant testing guidelines.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hartnack</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Animal Hygiene and Veterinary Public Health, University of Leipzig, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Essbauer</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Truyen</LastName><ForeName>U</ForeName><Initials>U</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Zoonoses Public Health</MedlineTA><NlmUniqueID>101300786</NlmUniqueID><ISSNLinking>1863-1959</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004202">Disinfectants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012900">Smallpox Vaccine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004202" MajorTopicYN="N">Disinfectants</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004203" MajorTopicYN="N">Disinfection</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012899" MajorTopicYN="N">Smallpox</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012900" MajorTopicYN="N">Smallpox Vaccine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014615" MajorTopicYN="N">Vaccinia</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014616" MajorTopicYN="N">Vaccinia virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012901" MajorTopicYN="N">Variola virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>2</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>5</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>2</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18234028</ArticleId><ArticleId IdType="pii">JVB1094</ArticleId><ArticleId IdType="doi">10.1111/j.1863-2378.2007.01094.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>District de Leipzig</li><li>Saxe (Land)</li></region><settlement><li>Leipzig</li></settlement></list><tree><noCountry><name sortKey="Essbauer, S" sort="Essbauer, S" uniqKey="Essbauer S" first="S" last="Essbauer">S. Essbauer</name><name sortKey="Truyen, U" sort="Truyen, U" uniqKey="Truyen U" first="U" last="Truyen">U. Truyen</name></noCountry><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Hartnack, S" sort="Hartnack, S" uniqKey="Hartnack S" first="S" last="Hartnack">S. Hartnack</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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